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Home - Products - Chromatin/Epigenetic - Epigenetic Reader Domain - Hematoporphyrin dihydrochloride

Hematoporphyrin dihydrochloride

CAS No. 17696-69-4

Hematoporphyrin dihydrochloride( Hematoporphyrin IX dihydrochloride )

Catalog No. M18132 CAS No. 17696-69-4

Hematoporphyrin dihydrochloride is a substrate for affinity chromatography of heme-binding proteins.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Hematoporphyrin dihydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Hematoporphyrin dihydrochloride is a substrate for affinity chromatography of heme-binding proteins.
  • Description
    Hematoporphyrin dihydrochloride is a substrate for affinity chromatography of heme-binding proteins.
  • In Vitro
    Cell Viability Assay Cell Line:U87 and U251 cells Concentration:20, 40, 60, 80, 100, 120 nM Incubation Time:60 min Result:Inhibited cell viability in a dose-dependent manner.Was more effective under the red light than white light.Apoptosis Analysis Cell Line:U87 cells Concentration:85 nM Incubation Time:60 min Result:Induced apoptotic nuclei in U87 cells with low cell density.Induced the ROS and decreased the mitochondrial membrane potential.
  • In Vivo
    Animal Model:Wistar albino rats of both sexes (20 d; 60-80 g) bearing a subcutaneous solid Yoshida hepatoma AH-130Dosage:5, 10 mg/kg Administration:I.p. daily during the initial 10 days and biweekly for the next 2 months Result:No tumor could be palpated a few days after exposure of the rats to light.The skin healed completely and regrowth of the hair occurred.Massive coagulation necrosis of the tumor 24 h after photo treatment (×40).
  • Synonyms
    Hematoporphyrin IX dihydrochloride
  • Pathway
    Chromatin/Epigenetic
  • Target
    Epigenetic Reader Domain
  • Recptor
    Others
  • Research Area
    Others-Field
  • Indication
    ——

Chemical Information

  • CAS Number
    17696-69-4
  • Formula Weight
    671.61
  • Molecular Formula
    C34H40Cl2N4O6
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 50 mg/mL 74.45 mM; H2O : < 0.1 mg/mL
  • SMILES
    Cl.C\1=c/2\[nH]/c(=C\C3=N/C(=C\c4[nH]c(c(c4C)CCC(=O)O)/C=C/4\N=C1C(=C4CCC(=O)O)C)/C(=C3C)C(C)O)/c(c2C)C(C)O.Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Olsen, K.W.Methods Enzymol, 1986. 123: p. 324-31.
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